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Transcranial Direct Current Stimulation (tDCS) and Transcranial Magnetic Stimulation (TMS) can be integrated as a "prime-and-probe" technique to investigate brain excitability and plasticity. tDCS applies a weak, constant electrical current to modulate cortical excitability, either increasing (anodal tDCS) or decreasing (cathodal tDCS) neuronal activity over a period. Following or during tDCS, TMS is used to probe the resultant changes in brain excitability or connectivity.
This combination allows researchers to assess the immediate and lasting effects of neuromodulation on specific brain circuits, making it valuable for understanding neuroplasticity mechanisms and optimizing therapeutic interventions for various neurological and psychiatric disorders.