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Integrating Transcranial Electrical Stimulation (tES) with Positron Emission Tomography (PET) allows for the study of tES-induced changes in brain metabolism, neurotransmitter systems, or receptor binding. While tES modulates brain activity, PET can measure various physiological and biochemical processes by detecting gamma rays from radiotracers. This combination is particularly valuable for investigating the long-term neurochemical effects of electrical stimulation, offering insights into how tES influences specific neurotransmitter pathways implicated in neurological and psychiatric disorders.